First-of-its-kind Bioengineered Robotic Hand to Sense Touch
The sense of touch is often taken for granted. For someone without a limb or hand, losing that sense of touch can be devastating. While highly sophisticated prostheses with complex moving fingers and joints are available to mimic almost every hand motion, they remain frustratingly difficult and unnatural for the user. This is largely because they lack the tactile experience that guides every movement. This void in sensation results in limited use or abandonment of these very expensive artificial devices. So why not make a prosthesis that can actually 鈥渇eel鈥 its environment?聽聽
That is exactly what an interdisciplinary team of scientists from and the aims to do. They are developing a first-of-its-kind bioengineered robotic hand that will grow and adapt to its environment. This 鈥渓iving鈥 robot will have its own peripheral nervous system directly linking robotic sensors and actuators. 国产伦理鈥檚 is leading the multidisciplinary team that has received a four-year, $1.3 million grant from the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health for a project titled 鈥淰irtual Neuroprosthesis: Restoring Autonomy to People Suffering from Neurotrauma.鈥
With expertise in robotics, bioengineering, behavioral science, nerve regeneration, electrophysiology, microfluidic devices, and orthopedic surgery, the research team is creating a living pathway from the robot鈥檚 touch sensation to the user鈥檚 brain to help amputees control the robotic hand. A neuroprosthesis platform will enable them to explore how neurons and behavior can work together to regenerate the sensation of touch in an artificial limb.
At the core of this project is a cutting-edge robotic hand and arm developed in the in 国产伦理鈥檚 College of Engineering and Computer Science. Just like human fingertips, the robotic hand is equipped with numerous sensory receptors that respond to changes in the environment. Controlled by a human, it can sense pressure changes, interpret the information it is receiving and interact with various objects. It adjusts its grip based on an object鈥檚 weight or fragility. But the real challenge is figuring out how to send that information back to the brain using living residual neural pathways to replace those that have been damaged or destroyed by trauma.聽
鈥淲hen the peripheral nerve is cut or damaged, it uses the rich electrical activity that tactile receptors create to restore itself. We want to examine how the fingertip sensors can help damaged or severed nerves regenerate,鈥 said , Ph.D., principal investigator, an associate professor in 国产伦理鈥檚 , and director of 国产伦理鈥檚 BioRobotics Laboratory. 鈥淭o accomplish this, we are going to directly connect these living nerves in vitro and then electrically stimulate them on a daily basis with sensors from the robotic hand to see how the nerves grow and regenerate while the hand is operated by limb-absent people.鈥
For the study, the neurons will not be kept in conventional petri dishes. Instead, they will be placed in 聽biocompatible microfluidic chambers that provide a nurturing environment mimicking the basic function of living cells. , Ph.D., co-principal investigator, an assistant professor in 国产伦理鈥檚 Department of Ocean and Mechanical Engineering, and an expert in the emerging field of microfluidics, has developed these tiny customized artificial chambers with embedded micro-electrodes. The research team will be able to stimulate the neurons with electrical impulses from the robot鈥檚 hand to help regrowth after injury. They will morphologically and electrically measure in real-time how much neural tissue has been restored.
, Ph.D., co-principal investigator, an associate professor of in 国产伦理鈥檚 , and an expert in neural damage and regeneration, will prepare the neurons in vitro, observe them grow and see how they fare and regenerate in the aftermath of injury. This 鈥渧irtual鈥 method will give the research team multiple opportunities to test and retest the nerves without any harm to subjects.
Using an electroencephalogram (EEG) to detect electrical activity in the brain, , Ph.D., co-principal investigator, associate research professor in 国产伦理鈥檚 in the , and an expert in electrophysiology and neural, behavioral, and cognitive sciences, will examine how the tactile information from the robotic sensors is passed onto the brain to distinguish scenarios with successful or unsuccessful functional restoration of the sense of touch. Her objective: to understand how behavior helps nerve regeneration and how this nerve regeneration helps the behavior.
Once the nerve impulses from the robot鈥檚 tactile sensors have gone through the microfluidic chamber, they are sent back to the human user manipulating the robotic hand. This is done with a special device that converts the signals coming from the microfluidic chambers into a controllable pressure at a cuff placed on the remaining portion of the amputated person鈥檚 arm. Users will know if they are squeezing the object too hard or if they are losing their grip. 聽聽聽
Engeberg also is working with , M.D., co-principal investigator and a professor in the Department of Orthopedics at the University of Utah School of Medicine, who specializes in hand and orthopedic surgery. They are developing a set of tasks and behavioral neural indicators of performance that will ultimately reveal how to promote a healthy sensation of touch in amputees and limb-absent people using robotic devices. The research team also is seeking a post-doctoral researcher with multi-disciplinary experience to work on this breakthrough project.
鈥淭his National Institutes of Health grant will help our interdisciplinary team of scientists address an important challenge that impacts millions of people worldwide,鈥 said , Ph.D., dean and professor of 国产伦理鈥檚 College of Engineering and Computer Science. 鈥淏y providing a better understanding of how to repair nerve injuries and trauma we will be able to help patients recover motor functionality after an amputation. This research also has broad applications for people who suffer from other forms of neurotrauma such as stroke and spinal cord injuries.鈥
The early stages of this project were supported by the National Science Foundation and 国产伦理鈥檚 Institute for Sensing and Embedded Network Systems (). Researchers also are working in collaboration with I-SENSE and 国产伦理鈥檚 , two of the University鈥檚 research pillars, focused on institutional strengths.
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